X0306 4 2021-12-10 0 0001659323 Iterum Therapeutics plc ITRM 0001792314 Puttagunta Sailaja C/O ITERUM THERAPEUTICS PLC FITZWILLIAM COURT, FL. 1, LEESON CLOSE DUBLIN 2 L2 IRELAND 0 1 0 0 Chief Medical Officer Share Option (Right to Buy) 0.48 2021-12-10 4 A 0 1800000 0.00 A 2031-12-09 Ordinary Shares 1800000 1800000 D Restricted Share Units 2021-12-10 4 A 0 500000 0.00 A Ordinary Shares 500000 500000 D The shares underlying this option shall vest at a rate of twenty-five percent of the total number of shares on the one-year anniversary of December 1, 2021 and the remaining 75% will vest in equal monthly installments thereafter until December 1, 2025, subject to the Reporting Person providing continuous service to the Issuer on each relevant vesting date. Each restricted share unit ("RSU") represents the contingent right to receive one ordinary share upon vesting of the RSU. Subject to the Reporting Person providing continuous service to the Issuer on each relevant vesting date and the other terms and conditions of the Issuer's 2021 Inducement Equity Incentive Plan, the RSUs shall vest over four years with 25% of the RSUs vesting on each one-year anniversary of December 1, 2021, such that the total number of RSUs shall be fully vested by December 1, 2025. /s/ Sailaja Puttagunta 2021-12-14