X0306 4 2021-03-11 0 0001659323 Iterum Therapeutics plc ITRM 0001734033 Matthews Judith M. C/O ITERUM THERAPEUTICS PLC, BLK 2 FL. 3, HARCOURT CENTRE, HARCOURT ST. DUBLIN L2 2 IRELAND 0 1 0 0 Chief Financial Officer Restricted Share Units 2021-03-11 4 A 0 200000 0.00 A Ordinary Shares 200000 200000 D Each restricted share unit ("RSU") represents the contingent right to receive one ordinary share upon vesting of the RSU. Subject to the reporting person providing continuous service to the Issuer on the relevant vesting date and the other terms and conditions of the Issuer's 2018 Amended and Restated Equity Incentive Plan, the RSUs shall vest 50% on March 11, 2022 and 50% on March 11, 2023. /s/ Judith M. Matthews 2021-03-15