X0306 4 2021-01-25 0 0001659323 Iterum Therapeutics plc ITRM 0001553594 Fishman Corey N. C/O ITERUM THERAPEUTICS PLC, BLK 2 FL. 3, HARCOURT CENTRE, HARCOURT ST. DUBLIN L2 2 IRELAND 1 1 0 0 President & CEO Ordinary Shares 2021-01-25 4 A 0 167500 0.00 A 407453 D Ordinary Shares 2021-01-26 4 S 0 85445 1.73 D 322008 D Consists of 167,500 ordinary shares received upon vesting of performance-based stock units ("PSUs") on January 25, 2021, which PSUs were subject to performance conditions that have been satisfied. PSUs convert into ordinary shares on a one-for-one basis. Represents the shares automatically sold by the reporting person pursuant to an election to satisfy tax withholding obligations in connection with the vesting of the PSUs. This sale does not represent a discretionary trade by the reporting person. /s/ Corey N. Fishman 2021-01-27