X0306 4 2020-06-10 0 0001659323 Iterum Therapeutics plc ITRM 0001624670 Kelly David George C/O ITERUM THERAPEUTICS PLC, BLK 2 FL. 3, HARCOURT CENTRE, HARCOURT ST. DUBLIN L2 2 IRELAND 1 0 0 0 Stock Option (Right to Buy) 1.68 2020-06-10 4 A 0 62840 0.00 A 2030-06-09 Ordinary Shares 62840 62840 D Subject to the reporting person providing continuous service to the Issuer and the other terms and conditions of the Issuer's 2018 Amended and Restated 2018 Equity Incentive Plan, the shares subject to this option shall vest in full on June 10, 2021 /s/ David George Kelly 2020-06-12