X0306 4 2019-06-13 0 0001659323 Iterum Therapeutics plc ITRM 0001322927 Ahrens Brenton Karl C/O CANAAN PARTNERS 285 RIVERSIDE AVE., SUITE 250 WESTPORT CT 06880 1 0 0 0 Stock Option (Right to Buy) 6.74 2019-06-13 4 A 0 19671 0.00 A 2029-06-12 Ordinary Shares 19671 19671 D Subject to the reporting person providing continuous service to the Issuer and the other terms and conditions of the Issuer's 2018 Equity Incentive Plan, the shares subject to this option shall vest on June 13, 2020. /s/ Janine MacDonald, Attorney-in-Fact for Brenton K. Ahrens 2019-06-17