X0306 4 2019-05-24 0 0001659323 Iterum Therapeutics plc ITRM 0001245624 HEALY JAMES C/O ITERUM THERAPEUTICS PLC, BLK 2 FL. 3, HARCOURT CENTRE, HARCOURT ST. DUBLIN L2 2 IRELAND 1 0 1 0 Ordinary Shares 2019-05-24 4 M 0 6154 A 6154 D Ordinary Shares 1726514 I By Sofinnova Venture Partners IX, L.P. Restricted Stock Units 2019-05-24 4 M 0 6154 0.00 D Ordinary Shares 6154 0 D Restricted stock units converted into ordinary shares on a one-for-one basis upon vesting of the units. These shares are held directly by Sofinnova Venture Partners IX, L.P. (the "Fund"). The general partner of the Fund is Sofinnova Management IX, L.L.C. (the "GP") and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by the Fund. Dr. James I. Healy, Michael F. Powell, Ph.D., and Dr. Anand Mehra are the managing members of the GP and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by the Fund. The reporting person disclaims beneficial ownership of such shares, except to the extent of his proportionate pecuniary interest therein, if any. On May 24, 2018, the reporting person was granted an award of 6,154 restricted stock units, which vested on May 24, 2019. /s/ James I. Healy 2019-05-29