X0306 4 2019-05-24 0 0001659323 Iterum Therapeutics plc ITRM 0001365617 Heron Patrick J C/O ITERUM THERAPEUTICS PLC, BLK 2 FL. 3, HARCOURT CENTRE, HARCOURT ST. DUBLIN L2 2 IRELAND 1 0 1 0 Ordinary Shares 2019-05-24 4 M 0 6154 A 6154 D Ordinary Shares 1197161 I By Frazier Healthcare VII, L.P. Ordinary Shares 341155 I By Frazier Healthcare VII-A, L.P. Restricted Stock Units 2019-05-24 4 M 0 6154 0.00 D Ordinary Shares 6154 0 D Restricted stock units converted into ordinary shares on a one-for-one basis upon vesting of the units. These shares are held directly by Frazier Healthcare VII, L.P. ("FH VII"). The sole general partner of FH VII is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VII. The reporting person is one of six members of FHM VII, L.L.C. The reporting person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VII, except to the extent of his or its pecuniary interest therein, if any. These shares are held directly by Frazier Healthcare VII-A, L.P. ("FH VIIA"). The sole general partner of FH VIIA is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VIIA. The reporting person is one of six members of FHM VII, L.L.C. The reporting person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VIIA, except to the extent of his or its pecuniary interest therein, if any. On May 24, 2018, the reporting person was granted an award of 6,154 restricted stock units, which vested on May 24, 2019. /s/ Patrick J. Heron 2019-05-28