X0306 4 2019-02-15 0 0001659323 Iterum Therapeutics plc ITRM 0001553594 Fishman Corey N. C/O ITERUM THERAPEUTICS PLC, BLK 2 FL. 3, HARCOURT CENTRE, HARCOURT ST. DUBLIN L2 2 IRELAND 1 1 0 0 President & CEO Stock Option (Right to Buy) 5.80 2019-02-15 4 A 0 150000 0.00 A 2029-02-14 Ordinary Shares 150000 150000 D The shares subject to this option shall vest at a rate of twenty-five percent of the total number of shares on the one-year anniversary of February 15, 2019 (the "Vesting Commencement Date") and 1/48th of the total number of shares each monthly anniversary of the Vesting Commencement Date thereafter for so long as the Reporting Person provides continuous service to the Issuer, such that the total number of shares shall be fully vested on the four-year anniversary of the Vesting Commencement Date. /s/ Judith M. Matthews as attorney in fact 2019-02-18