X0306 4 2023-01-06 0 0001658551 Amylyx Pharmaceuticals, Inc. AMLX 0001358266 Yeramian Patrick D C/O AMYLYX PHARMACEUTICALS, INC. 43 THORNDIKE STREET CAMBRIDGE MA 02142 0 1 0 0 Chief Medical Officer Common Stock 2023-01-06 4 S 0 1405 36.0789 A 204928 D Common Stock 2023-01-06 4 S 0 629 36.7888 A 204299 D Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. These sales were automatic and intended to qualify under Rule 10b5-1. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.59 to $36.58. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $36.59 to $37.01. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. /s/ Joshua B. Cohen, as Attorney in Fact 2023-01-10