144 0001746298 XXXXXXXX LIVE 0001658247 Crinetics Pharmaceuticals, Inc. 001-38583 10222 BARNES CANYON ROAD, BLDG. #2 SAN DIEGO CA 92121 858-450-6464 Struthers Richard Scott Officer Common UBS Financial Services, Inc.

1000 Harbor Boulevard Weehawken NJ 07086

14157 288154.41 54026103 07/13/2023 NASDAQ Common 07/31/2011 Founder Shares Issuer N 14157 07/31/2011 N/A N Richard Scott Struthers

c/o 10222 Barnes Canyon Road Bldg #2 San Diego CA 92121

Common 06/16/2023 50000 1040660.00 Richard Scott Struthers

c/o 10222 Barnes Canyon Road Bldg #2 San Diego CA 92121

Common 07/11/2023 24384 491118.14 Richard Scott Struthers

c/o 10222 Barnes Canyon Road Bldg #2 San Diego CA 92121

Common 07/12/2023 11459 231171.57 The shares covered under this filing are being sold by the Struthers Family Trust dtd 8-3-2006 07/13/2023 03/18/2023 /s/ UBS Financial Services Inc, as attorney-in-fact for Richard Scott Struthers