144 0001881007 XXXXXXXX LIVE 0001658247 Crinetics Pharmaceuticals Inc 001-38583 6055 Lusk Boulevard San Diego CA 92121 8584506464 Jeff Knight Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

25113 941486 104705300 03/16/2026 Nasdaq Common 03/15/2026 Restricted Stock Unit Vesting Issuer N 25113 03/15/2026 Compensation Y The Reporting Person is selling the securities set forth herein pursuant to a mandatory, non-discretionary, sell-to-cover arrangement for the purpose of satisfying income tax liabilities incurred upon vesting of restricted stock unit awards. 03/16/2026 /s/ Tobin Schilke as attorney-in-fact