X0508 4 2024-03-18 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001881007 Knight Jeff E. C/O CRINETICS PHARMACEUTICALS, INC. 6055 LUSK BOULEVARD SAN DIEGO CA 92121 0 1 0 0 Chief Operating Officer 1 Common Stock 2024-03-18 4 F 0 4283 38.14 D 54939 D Represents the number of shares of common stock withheld by the Issuer to cover the reporting person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022 and March 1, 2023. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person. /s/ Marc Wilson, as attorney-in-fact 2024-03-20