X0508 4 2023-10-17 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001435775 Krasner Alan Seth C/O CRINETICS PHARMACEUTICALS, INC. 10222 BARNES CANYON ROAD, BLDG 2 SAN DIEGO CA 92121 0 1 0 0 Chief Medical Officer 1 Common Stock 2023-10-17 4 M 0 7000 12.01 A 50210 D Common Stock 2023-10-17 4 S 0 7000 30.00 D 43210 D Non-qualified stock option (Right to Buy) 12.01 2023-10-17 4 M 0 7000 0.00 D 2028-06-15 Common Stock 7000 153473 D Includes 909 shares acquired under the Issuer's Employee Stock Purchase Plan since the last Section 16 filing by the Reporting Person. 25% of the shares subject to the option vest on June 16, 2019, and 1/48th of the shares subject to the option vest monthly thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. The stock options are also subject to accelerated vesting as set forth in the employment agreement between the Issuer and the Reporting Person. /s/ Marc Wilson, as attorney-in-fact 2023-10-19