X0407 4 2023-06-16 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001326969 Bedrosian Camille L C/O CRINETICS PHARMACEUTICALS, INC. 10222 BARNES CANYON ROAD, BLDG 2 SAN DIEGO CA 92121 1 0 0 0 0 Common Stock 2023-06-16 4 A 0 6000 0.00 A 6000 D Stock Option (right to buy) 20.32 2023-06-16 4 A 0 17500 0.00 A 2033-06-15 Common Stock 17500 17500 D The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date. The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date. /s/ Marc Wilson 2023-06-21