X0306 4 2023-03-16 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001435775 Krasner Alan Seth C/O CRINETICS PHARMACEUTICALS, INC. 10222 BARNES CANYON ROAD, BLDG 2 SAN DIEGO CA 92121 0 1 0 0 Chief Medical Officer Common Stock 2023-03-16 4 F 0 1687 17.12 D 42301 D Represents the number of shares of common stock withheld by the Issuer to cover the reporting person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person. /s/ Marc Wilson, as attorney-in-fact 2023-03-17