X0306 4 2022-06-17 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001610381 Vivaldi Coelho Rogerio C/O CRINETICS PHARMACEUTICALS, INC. 10222 BARNES CANYON ROAD, BLDG 2 SAN DIEGO CA 92121 1 0 0 0 Stock Option (right to buy) 18.29 2022-06-17 4 A 0 8750 0.00 A 2032-06-16 Common Stock 8750 8750 D The entire number of shares subject to this option become fully vested and exercisable on the first to occur of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date. /s/ Marc Wilson, as attorney-in-fact 2022-06-21