X0306 4 2022-04-05 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001746298 Struthers Richard Scott C/O CRINETICS PHARMACEUTICALS, INC. 10222 BARNES CANYON ROAD, BLDG 2 SAN DIEGO CA 92121 1 1 0 0 President & CEO Common Stock 2022-04-05 4 S 0 21357 25.3418 D 869448 I By Family Trust 1 Common Stock 57400 D Common Stock 1000 I By Spouse Common Stock 90000 I By Family Trust 2 Common Stock 90000 I By Family Trust 3 Common Stock 90000 I By Family Trust 4 The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 30 days prior to the trading date. The common stock was sold by the reporting person in open market transactions on the transaction date, with a volume weighted average sales price of $25.3418 per share. The range of actual sales prices on the transaction date was $25.00 to $25.57 per share. Detailed information on the exact number of shares sold at each price can be obtained from the issuer upon request. /s/ Marc Wilson, as attorney-in-fact 2022-04-07