X0306 4/A 2022-03-11 2022-03-14 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001871152 Deardorf Caren C/O CRINETICS PHARMACEUTICALS, INC. 10222 BARNES CANYON ROAD, BLDG 2 SAN DIEGO CA 92121 1 0 0 0 Stock Option (right to buy) 19.30 2022-03-11 4 A 0 35000 0.00 A 2032-03-10 Common Stock 35000 35000 D On March 14, 2022, the reporting person filed a Form 4 which inadvertently reported that she was granted an option to purchase 25,000 shares of the issuer's common stock. In fact, as reported in this amendment, the reporting person was granted an option to purchase 35,000 shares of common stock. The Option shall vest and become exercisable in three substantially equal annual installments on each of the first three anniversaries of the date of grant, subject to continued service as a director through each such vesting date. /s/ Marc Wilson, as attorney-in-fact 2022-04-04