X0306 4 2022-02-28 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001746298 Struthers Richard Scott C/O CRINETICS PHARMACEUTICALS, INC. 10222 BARNES CANYON ROAD, BLDG 2 SAN DIEGO CA 92121 1 1 0 0 President & CEO Common Stock 2022-02-28 4 A 0 53400 0.00 A 57400 D Common Stock 1000 I By Spouse Common Stock 890805 I By Family Trust 1 Common Stock 90000 I By Family Trust 2 Common Stock 90000 I By Family Trust 3 Common Stock 90000 I By Family Trust 4 Common Stock (right to buy) 20.02 2022-02-28 4 A 0 249200 0.00 A 2032-02-27 Common Stock 249200 249200 D The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 15, 2023.. The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 28, 2022. /s/ Marc Wilson, as attorney-in-fact 2022-03-02