X0306 4 2022-02-28 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001807856 Madan Ajay C/O CRINETICS PHARMACEUTICALS, INC. 10222 BARNES CANYON ROAD, BLDG 2 SAN DIEGO CA 92121 0 1 0 0 Chief Development Officer Common Stock 2022-02-28 4 A 0 13950 0.00 A 185995 D Common Stock 2022-03-01 4 S 0 9000 19.88 A 176995 D Common Stock (right to buy) 20.02 2022-02-28 4 A 0 65400 0.00 A 2032-02-27 Common Stock 65400 65400 D The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 15, 2023. The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 30 days prior to the trading date. The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 28, 2022. /s/ Marc Wilson, as attorney-in-fact 2022-03-02