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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Operating activities:        
Net loss $ (42,375,000) $ (26,095,000) $ (77,002,000) $ (48,996,000)
Reconciliation of net loss to net cash used in operating activities:        
Stock-based compensation     12,886,000 7,639,000
Depreciation and amortization     455,000 454,000
Noncash lease expense     195,000 163,000
Accretion of purchase discounts and amortization of premiums on investment securities, net     517,000 170,000
Loss on equity method investment 0 0 1,010,000 0
Change in valuation of derivative asset (31,000) (31,000)
Other, net     0 (1,000)
Increase (decrease) in cash resulting from changes in:        
Prepaid expenses and other assets     3,234,000 (941,000)
Accounts payable and accrued expenses     8,241,000 1,901,000
Deferred revenue     9,431,000 0
Operating lease liability     (455,000) (405,000)
Net cash used in operating activities     (41,519,000) (40,016,000)
Investing activities:        
Purchases of investment securities     (247,572,000) (2,535,000)
Maturities of investment securities     30,617,000 55,153,000
Purchases of property and equipment     (700,000) (278,000)
Net cash (used in) provided by investing activities     (217,655,000) 52,340,000
Financing activities:        
Proceeds from issuance of common stock, net of $7.8 million (2022) and $2.4 million (2021) of transaction costs     117,255,000 72,558,000
Proceeds from exercise of stock options     3,517,000 802,000
Net Cash Provided by (Used in) Financing Activities, Total     120,772,000 73,360,000
Net change in cash, cash equivalents and restricted cash     (138,402,000) 85,684,000
Cash, cash equivalents and restricted cash at beginning of period     201,195,000 93,587,000
Cash, cash equivalents and restricted cash at end of period 62,793,000 179,271,000 62,793,000 179,271,000
Components of cash, cash equivalents and restricted cash:        
Cash and cash equivalents 62,293,000 178,771,000 62,293,000 178,771,000
Restricted cash 500,000 500,000 500,000 500,000
Cash, cash equivalents and restricted cash at end of period $ 62,793,000 $ 179,271,000 62,793,000 179,271,000
Noncash investing and financing activities:        
Change in unvested stock liability     2,000 11,000
Stock issued under Stock Purchase Plan     813,000 522,000
Amounts accrued for follow-on offering costs     13,000 0
Amounts accrued for purchases of property and equipment     $ 82,000 $ 0