X0202 SCHEDULE 13G/A 0000938206 XXXXXXXX LIVE 3 Common Stock 03/31/2026 0001658247 Crinetics Pharmaceuticals, Inc. 22663K107 10222 Barnes Canyon Road, Bldg. 2 San Diego CA 92121 Rule 13d-1(b) DRIEHAUS CAPITAL MANAGEMENT LLC DE 0 6395922 0 6395922 6395922 6.11 IA This amendment is filed to reflect the change in our percentage of ownership of Crinetics Pharmaceuticals, Inc. (CRNX). DCM owned 6.11% of CRNX as of March 31, 2026, down from 7.54% as of December 31, 2023. Crinetics Pharmaceuticals, Inc. 10222 Barnes Canyon Road, Bldg, 2, San Diego, CA 92121 Driehaus Capital Management LLC 25 East Erie Street Chicago, IL 60611 USA N IA 6395922 6.11% 0 6395922 0 6395922 Y N The shares reported by Driehaus Capital Management LLC (DCM) are held by numerous clients on a fully discretionary basis in accounts managed by DCM. Securities held in these clients' accounts are included in this report to reflect that DCM may have voting power and has dispositive power. To the best of DCM's knowledge, none of the referenced clients have the right to receive dividends or direct proceeds from the sale of interests relating to more than 5% of the class. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. DRIEHAUS CAPITAL MANAGEMENT LLC Janet McWilliams 05/15/2026