X0306 4 2020-07-02 0 0001631574 Wave Life Sciences Ltd. WVE 0001657710 BOLNO PAUL C/O WAVE LIFE SCIENCES LTD., 733 CONCORD AVE. CAMBRIDGE MA 02138 1 1 0 0 President and CEO Ordinary Shares 2020-07-02 4 S 0 4509 10.82 D 315249 D Ordinary Shares 2020-07-02 4 S 0 43068 10.26 D 272181 D Ordinary Shares 2020-07-02 4 M 0 100000 2.48 A 372181 D Ordinary Shares 2020-07-02 4 S 0 4079 10.91 D 368102 D Ordinary Shares 2020-07-02 4 S 0 95921 10.27 D 272181 D Share Option (right to buy) 2.48 2020-07-02 4 M 0 100000 0.00 D 2025-03-10 Ordinary Shares 100000 222778 D Consists of the sale of shares that were issued upon the vesting of restricted share units. The sale was effected pursuant to a Rule 10b5-1 trading plan. The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $10.78 to $11.12 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price. The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $9.77 to $10.77 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price. The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. These share options are fully vested. /s/ Paul B. Bolno 2020-07-02