X0306 4 2022-02-16 0 0001631574 Wave Life Sciences Ltd. WVE 0001657675 Vargeese Chandra C/O WAVE LIFE SCIENCES LTD., 733 CONCORD AVE. CAMBRIDGE MA 02138 0 1 0 0 Chief Technology Officer Ordinary Shares 2022-02-16 4 S 0 10603 2.32 D 77809 D On February 16, 2022, the reporting person sold 10,603 ordinary shares solely to cover taxes associated with the vesting of restricted share units ("RSUs") on February 15, 2022. These sales were made pursuant to a provision in the reporting person's RSU agreement that requires automatic sales of shares to cover tax withholding obligations. The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $2.31 to $2.38 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price. Includes 1,500 ordinary shares acquired on July 14, 2021, and 1,500 ordinary shares acquired on January 14, 2022, under the issuer's 2019 Employee Share Purchase Plan (ESPP). /s/ Chandra Vargeese 2022-02-18