X0101 EFFECT 33 LIVE 2018-04-04 16:00:00

N-1A

0001657201 PowerShares Exchange-Traded Self-Indexed Fund Trust 333-221046 S000060831 PowerShares BulletShares 2027 Corporate Bond Portfolio C000197647 PowerShares BulletShares 2027 Corporate Bond Portfolio S000060832 PowerShares BulletShares 2021 High Yield Corporate Bond Portfolio C000197648 PowerShares BulletShares 2021 High Yield Corporate Bond Portfolio S000060833 PowerShares BulletShares 2022 Corporate Bond Portfolio C000197649 PowerShares BulletShares 2022 Corporate Bond Portfolio S000060834 PowerShares BulletShares 2022 High Yield Corporate Bond Portfolio C000197650 PowerShares BulletShares 2022 High Yield Corporate Bond Portfolio S000060835 PowerShares BulletShares 2023 Corporate Bond Portfolio C000197651 PowerShares BulletShares 2023 Corporate Bond Portfolio S000060836 PowerShares BulletShares 2023 High Yield Corporate Bond Portfolio C000197652 PowerShares BulletShares 2023 High Yield Corporate Bond Portfolio S000060837 PowerShares BulletShares 2024 Corporate Bond Portfolio C000197653 PowerShares BulletShares 2024 Corporate Bond Portfolio S000060838 PowerShares BulletShares 2024 High Yield Corporate Bond Portfolio C000197654 PowerShares BulletShares 2024 High Yield Corporate Bond Portfolio S000060839 PowerShares BulletShares 2025 Corporate Bond Portfolio C000197655 PowerShares BulletShares 2025 Corporate Bond Portfolio S000060840 PowerShares BulletShares 2026 Corporate Bond Portfolio C000197656 PowerShares BulletShares 2026 Corporate Bond Portfolio S000060841 PowerShares Defensive Equity Portfolio C000197657 PowerShares Defensive Equity Portfolio S000060842 PowerShares BulletShares 2025 High Yield Corporate Bond Portfolio C000197658 PowerShares BulletShares 2025 High Yield Corporate Bond Portfolio S000060843 PowerShares U.S. Large Cap Optimized Volatility Portfolio C000197659 PowerShares U.S. Large Cap Optimized Volatility Portfolio S000060844 PowerShares Multi-Factor Large Cap Portfolio C000197660 PowerShares Multi-Factor Large Cap Portfolio S000060845 PowerShares BulletShares 2018 Corporate Bond Portfolio C000197661 PowerShares BulletShares 2018 Corporate Bond Portfolio S000060846 PowerShares BulletShares 2018 High Yield Corporate Bond Portfolio C000197662 PowerShares BulletShares 2018 High Yield Corporate Bond Portfolio S000060847 PowerShares BulletShares 2019 Corporate Bond Portfolio C000197663 PowerShares BulletShares 2019 Corporate Bond Portfolio S000060848 PowerShares BulletShares 2019 High Yield Corporate Bond Portfolio C000197664 PowerShares BulletShares 2019 High Yield Corporate Bond Portfolio S000060849 PowerShares BulletShares 2020 Corporate Bond Portfolio C000197665 PowerShares BulletShares 2020 Corporate Bond Portfolio S000060850 PowerShares BulletShares 2020 High Yield Corporate Bond Portfolio C000197666 PowerShares BulletShares 2020 High Yield Corporate Bond Portfolio S000060851 PowerShares BulletShares 2021 Corporate Bond Portfolio C000197667 PowerShares BulletShares 2021 Corporate Bond Portfolio