Nature of Business and Basis of Presentation (Details) $ in Millions	12 Months Ended
	Dec. 31, 2021 USD ($) Subsidiary
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of wholly owned subsidiaries | Subsidiary	4
Gross proceeds from sale of equity instruments and exercise of options	$ 1,300.0
Payments received from collaboration partners	774.0
Cash, cash equivalents, restricted cash and marketable securities	$ 1,500.0