X0306 4 2022-02-23 0 0001655759 ARVINAS, INC. ARVN 0001421914 Cassidy Sean A C/O ARVINAS, INC. 5 SCIENCE PARK, 395 WINCHESTER AVE. NEW HAVEN CT 06511 0 1 0 0 Chief Financial Officer Common Stock 2022-03-04 4 M 0 4791 A 163040 D Common Stock 2022-03-04 4 S 0 1593 63.94 D 161447 D Stock Option (right to buy) 64.19 2022-02-23 4 A 0 67000 0.00 A 2032-02-22 Common Stock 67000 67000 D Restricted Stock Units 2022-03-04 4 M 0 4791 0.00 D Common Stock 4791 4791 D Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock. This sale was made to cover withholding taxes following the vesting of previously granted Restricted Stock Units. The broker sold shares of the Issuer's common stock for certain employees following the vesting of previously granted Restricted Stock Units, including the common stock reported on this Form 4 by the reporting person, at an average price of $63.94. This option award was granted on February 23, 2022. 1/4 of the shares underlying the award shall vest on February 23, 2023, with the remainder of the shares vesting in equal monthly installments following February 23, 2023 through February 23, 2026. On March 1, 2019, the reporting person was granted 19,165 Restricted Stock Units, vesting in four equal annual installments beginning March 1, 2020. /s/ Matthew Batters as attorney-in-fact for Sean Cassidy 2022-03-04