X0306 4 2017-09-13 0 0001645113 Novocure Ltd NVCR 0001654363 Ambrogi Michael J. C/O NOVOCURE INC. 20 VALLEY STREAM PARKWAY, SUITE 300 MALVERN PA 19355 0 1 0 0 Chief Operating Officer Ordinary Shares 2017-09-13 4 D 0 76327 22.0174 D 57760 D Ordinary Shares 2017-09-14 4 D 0 1746 22.0029 D 56014 D On September 13, 2017, pursuant to a Rule 10b5-1 trading plan adopted by Mr. Ambrogi, Mr. Ambrogi sold 76,327 shares in multiple trades at prices ranging from $22.00 to $22.10. The price reported above reflects the weighted average sale price. Mr. Ambrogi hereby undertakes to provide to the Staff, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares and prices at which the transaction was effected. On September 14, 2017, pursuant to a Rule 10b5-1 trading plan adopted by Mr. Ambrogi, Mr. Ambrogi sold 1,746 shares in multiple trades at prices ranging from $22.00 to $22.05. The price reported above reflects the weighted average sale price. Mr. Ambrogi hereby undertakes to provide to the Staff, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares and prices at which the transaction was effected. /s/ Kimberly Burke, Attorney in fact for Michael J. Ambrogi 2017-09-15