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Income Taxes - Reconciliation of U.S. Federal Statutory Income Tax Rate to Effective Income Tax Rate (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
Federal statutory income tax rate 21.00% 21.00% 21.00%
State taxes, including credits, net of federal benefit 3.20% 2.40% 7.00%
Federal research and orphan drug credit 2.50% 2.10% 5.40%
Stock-based compensation 0.10% 5.40% 4.70%
Permanent adjustments and other (0.30%) 0.50% (0.90%)
Increase in deferred tax asset valuation allowance (26.50%) (31.40%) (37.20%)
Effective income tax rate 0.00% 0.00% 0.00%