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Restructuring and Related Activities (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Dec. 31, 2021
Dec. 31, 2021
Dec. 31, 2021
Nov. 30, 2021
Restructuring Cost and Reserve [Line Items]        
Restructuring Charges   $ 26,170    
Restructuring Costs and Asset Impairment Charges   (2,927)    
Restructuring Reserve $ 20,791 20,791 $ 20,791 $ 23,243
Payments for Restructuring (2,452)      
Research and development        
Restructuring Cost and Reserve [Line Items]        
Restructuring Charges     22,200  
Selling, general, and administrative        
Restructuring Cost and Reserve [Line Items]        
Restructuring Charges     4,000  
Workforce Reduction        
Restructuring Cost and Reserve [Line Items]        
Restructuring Charges   9,835    
Restructuring Costs and Asset Impairment Charges   0    
Restructuring Reserve 7,383 7,383 7,383 9,835
Payments for Restructuring (2,452)      
Pipeline programs        
Restructuring Cost and Reserve [Line Items]        
Restructuring Charges   16,400 16,335  
Restructuring Costs and Asset Impairment Charges   (2,927)    
Restructuring Reserve 13,408 $ 13,408 $ 13,408 $ 13,408
Payments for Restructuring $ 0