Net Loss per Share (Tables)

12 Months Ended

Dec. 31, 2021

Earnings Per Share [Abstract]

Summary of Basic and Diluted Net Loss per Share

Basic and diluted net loss per share was calculated as follows:

	Year Ended December 31,
(in thousands, except share and per share amounts)	2021		2020		2019
Numerator:
Net loss	$	(299,964)	$	(266,489)	$	(192,256)
Denominator:
Weighted average common shares outstanding—basic and diluted	58,084,325		55,780,982		42,869,058
Net loss per share—basic and diluted	$	(5.16)	$	(4.78)	$	(4.48)

Summary of Potential Dilutive Securities

The following potential dilutive securities, presented based on amounts outstanding at the end of each reporting period, have been excluded from the calculation of diluted net loss per share because including them would have had an anti-dilutive impact:

	As of December 31,
	2021	2020	2019
Options to purchase common stock	7,439,508	5,712,339	6,750,939
Unvested restricted stock units	1,537,732	438,625	156,900
Unvested employee stock purchase plan shares	211,822	30,826	—
Total	9,189,062	6,181,790	6,907,839