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Accrued Expenses and Other Current Liabilities (Tables)
 12 Months Ended
Dec. 31, 2021
Payables and Accruals [Abstract]  
Schedule of Accrued Expenses
December 31,
(in thousands)20212020
External research and development expenses$32,619 $31,259 
Restructuring reserve20,790 — 
Payroll and related expenses11,945 17,255 
Revenue-related reserves8,722 3,018 
Professional fees5,626 3,306 
Other1,071 389 
Total accrued expenses and other current liabilities$80,773 $55,227