Amount of grants awarded Cash Proceed From Research And Development Grants Cash proceed from research and development grants. Revenue from Contract with Customer [Abstract] Development And Commercial Milestone Development And Commercial Milestone [Member] Title of Individual [Axis] Title of Individual [Axis] Other Commitments [Table] Other Commitments [Table] Level 3 Fair Value, Inputs, Level 3 [Member] City Area Code City Area Code External research and development expenses Accrued Research And Development Expenses Carrying value as of the balance sheet date of obligations incurred through that date and payable for research and development expenses. Initial annual base rent expense Operating Leases Rent Expense Annual The annual base rent expense for an operating lease. Stock-based compensation expense APIC, Share-based Payment Arrangement, Increase for Cost Recognition Minimum rental expense Operating Leases, Rent Expense, Minimum Rentals Prepaid expenses and other current assets Increase (Decrease) in Prepaid Expense and Other Assets Total current liabilities Liabilities, Current Title of 12(b) Security Title of 12(b) Security Accrued expenses and other current liabilities Total accrued expenses and other current liabilities Accrued Liabilities and Other Liabilities Total Assets, Fair Value Disclosure Short-term marketable securities Marketable Securities KBA Grants KBA Grants [Member] KBA grants. Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Inventory purchases included in accrued expenses and other current liabilities Noncash or Part Noncash Acquisition, Inventory Acquired Other comprehensive income (loss): Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Recently Issued Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Cost of sales Cost of Goods and Services Sold SEC Schedule, 12-09, Valuation Allowances and Reserves [Domain] SEC Schedule, 12-09, Valuation Allowances and Reserves [Domain] Current Fiscal Year End Date Current Fiscal Year End Date Assets Assets [Abstract] Proceeds from public offerings, net of underwriting discounts and commissions Proceeds from Issuance of Common Stock Revenues Revenues Beginning balance (in shares) Ending balance (in shares) Shares, Outstanding Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Entity Ex Transition Period Entity Ex Transition Period Provision related to sales in the current year Provision To Product Revenue Reserves Relating To Sales In Current Year Provision to product revenue reserves relating to sales in current year. Entity Address, Postal Zip Code Entity Address, Postal Zip Code Short-term Debt, Type [Domain] Short-term Debt, Type [Domain] President And Chief Executive Officer President And Chief Executive Officer [Member] President And Chief Executive Officer [Member] Issuance of common stock sold in public offering, net of underwriting discounts, commissions and offering costs Stock Issued During Period, Value, New Issues Payables and Accruals [Abstract] Payables and Accruals [Abstract] Cash flows from operating activities: Net Cash Provided by (Used in) Operating Activities [Abstract] Development Milestone Development Milestone [Member] Unvested performance-based restricted common stock units Performance Shares Performance Shares [Member] Property and equipment, net Property, Plant and Equipment, Net Other income (expense): Nonoperating Income (Expense) [Abstract] Accumulated Other Comprehensive Income (Loss) AOCI Attributable to Parent [Member] Total assets Assets Entity Shell Company Entity Shell Company Cover [Abstract] Document Type Document Type Milestone Two [Domain] Milestone Two [Domain] Amortized Cost, due within one year Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Rolling within One Year, Amortized Cost Issuance of common stock upon exercise of stock options Stock Issued During Period, Value, Stock Options Exercised Net loss per share—basic and diluted (in dollars per share) Earnings Per Share, Basic and Diluted Customer [Domain] Customer [Domain] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Share-based Payment Arrangement [Abstract] Milestone [Axis] Milestone [Axis] Accounts Receivable Increase (Decrease) in Accounts Receivable Schedule of Inventory Schedule of Inventory, Current [Table Text Block] Current liabilities: Liabilities, Current [Abstract] Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] Income Statement Location [Domain] Income Statement Location [Domain] Range [Axis] Statistical Measurement [Axis] Repayment of notes payable to related party Repayments of Related Party Debt Inventory Inventory, Policy [Policy Text Block] Financial Instrument [Axis] Financial Instrument [Axis] Preferred Stock Preferred Stock [Member] Summary Of Total Product Revenue Reserves Included In The Consolidated Balance Sheets Summary Of Total Product Revenue Reserves Included In The Consolidated Balance Sheets [Table Text Block] Summary Of Total Product Revenue Reserves Included In The Consolidated Balance Sheets Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Stock-based compensation expense related to modification Share-based Payment Arrangement, Plan Modification, Incremental Cost Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Accounts payable Increase (Decrease) in Accounts Payable Document Quarterly Report Document Quarterly Report Commitments and contingencies (Note 6) Commitments and Contingencies Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Product Revenues Revenue from Contract with Customer [Policy Text Block] Cash and cash equivalents at beginning of period Cash and cash equivalents at end of period Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash equivalents: Cash and Cash Equivalents [Abstract] Weighted average common shares outstanding—basic and diluted (in shares) Weighted Average Number of Shares Outstanding, Basic and Diluted Analysis Of Amount Of And Change In Product Revenue Reserves. 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of Presentation, Business Description and Accounting Policies [Text Block] Amortized Cost, due after on year through five years Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Rolling after One Through Five Years, Amortized Cost Work in process Inventory, Work in Process, Net of Reserves Classification of Stock-Based Compensation Expense Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Entity Address, Address Line One Entity Address, Address Line One Business Combinations [Abstract] SEC Schedule, 12-09, Valuation Allowances and Reserves Type [Axis] SEC Schedule, 12-09, Valuation Allowances and Reserves Type [Axis] Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Comprehensive loss: Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Geographical [Domain] Geographical [Domain] Issuance of common stock upon exercise of stock options (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Gross Unrealized Losses, due within one year Debt Securities, Available-For-Sale, Maturity, Allocated And Single Maturity Date, Rolling Within One Year, Unrealized Loss Debt Securities, Available-For-Sale, Maturity, Allocated And Single Maturity Date, Rolling Within One Year, Unrealized Loss Share-based Compensation Arrangement by Share-based Payment Award, Discount from Market Price, Offering Date Share-based Compensation Arrangement by Share-based Payment Award, Discount from Market Price, Offering Date Entity Address, State or Province Entity Address, State or Province Income Statement Location [Axis] Income Statement Location [Axis] Estimated Fair Value, due within one year Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Rolling within One Year, Fair Value Options to extend terms of the lease Lessee, Operating Lease, Renewal Term Total current assets Assets, Current Entity Current Reporting Status Entity Current Reporting Status Customer Concentration Risk Customer Concentration Risk [Member] Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period Net cash flows used in investing activities Net Cash Provided by (Used in) Investing Activities Net increase (decrease) in cash and cash equivalents Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] Follow on Offering Follow on Offering [Member] Follow on Offering [Member] INTRIGUE Study Related Milestone INTRIGUE Study Related Milestone [Member] Net loss Net loss Net Income (Loss) Attributable to Parent Proceeds from exercise of stock options Proceeds from Stock Options Exercised Common Stock Common Stock [Member] Current assets: Assets, Current [Abstract] Investments, All Other Investments [Abstract] Investments, All Other Investments [Abstract] Nature Of Business And Basis Of Presentation [Line Items] Nature of Business and Basis of Presentation [Line Items] Nature of business and basis of presentation. Accounts payable Accounts Payable, Current Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Product and Service [Axis] Product and Service [Axis] Entity Small Business Entity Small Business Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Entity Interactive Data Current Entity Interactive Data Current Estimated Fair Value, due after on year through five years Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Rolling after One Through Five Years, Fair Value Common stock, shares issued (in shares) Common Stock, Shares, Issued Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Noncash lease expense Increase Decrease In Operating Lease Right Of Use Asset Amount of increase (decrease) in right-of-use assets under an operating lease. Total cost and operating expenses Costs and Expenses Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Agreement Type [Domain] Agreement Type [Domain] Entity Filer Category Entity Filer Category License Agreement [Abstract] License Agreement [Abstract] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Collaboration revenues Collaboration Arrangement [Member] Collaboration Arrangement Other Other Accrued Liabilities, Current Letter of Credit Letter of Credit [Member] Share-based compensation expense Share-based Payment Arrangement, Expense Inventory Inventory Inventory, Net Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Total liabilities and stockholders' equity Liabilities and Equity Entity Address, City or Town Entity Address, City or Town Selling, general, and administrative expenses Selling, General and Administrative Expenses [Member] Unvested time-based restricted common stock units Unvested Time Based Restricted Common Stock Units Member [Member] Unvested Time Based Restricted Common Stock Units Member Certificates of deposit Certificates of Deposit [Member] Major customer percentage of gross product revenues Concentration Risk, Percentage Accrued expenses and other current liabilities Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Marketable Securities [Table] Marketable Securities [Table] Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Gross Unrealized Gains, due within one year Debt Securities, Available-For-Sale, Maturity, Allocated And Single Maturity Date, Rolling Within One Year, Unrealized Gain Debt Securities, Available-For-Sale, Maturity, Allocated And Single Maturity Date, Rolling Within One Year, Unrealized Gain Operating lease liabilities, net of current portion Operating Lease, Liability, Noncurrent Equity Award [Domain] Award Type [Domain] Cost and operating expenses: Operating Expenses [Abstract] Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Upfront cash payment receivable License Agreement Upfront Payment Receivable The amount of upfront payment to be received as part of a license agreement. Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Long-term investments—restricted Restricted Investments, Noncurrent Issuance of common stock sold in public offering, net of underwriting discounts, commissions and offering costs (in shares) Number of shares issued and sold (in shares) Stock Issued During Period, Shares, New Issues Product Revenue Allowance and Reserves Product Revenue Allowance and Reserves - Accrued Expenses and Other Current Liabilities SEC Schedule, 12-09, Valuation and Qualifying Accounts Disclosure [Table] Gross Unrealized Losses Debt Securities, Available-for-sale, Unrealized Loss Stockholders' equity: Stockholders' Equity Attributable to Parent [Abstract] Document Fiscal Year Focus Document Fiscal Year Focus Marketable Securities [Line Items] Marketable Securities [Line Items] Sales of marketable securities Proceeds from Sale of Debt Securities, Available-for-sale Upfront payment recognized revenue License Agreement Upfront Payment Recognized Revenue The amount of revenue recognized during the period for the upfront payment of a license agreement. Subsequent Event Subsequent Events [Text Block] Research and development expenses Research and Development Expense [Member] License agreement milestone License Agreement Milestone The amount of milestone payment the Company is eligible to receive as part of a license agreement. Regulatory related development milestone Regulatory-related development milestone [Member] Regulatory-related development milestone U.S. government securities US Government Debt Securities [Member] Zai Supply Agreement Zai Supply Agreement [Member] Zai Supply Agreement Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Total liabilities Liabilities Unbilled Receivables Increase (Decrease) in Contract with Customer, Asset Summary of Potential Dilutive Securities Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Returns SEC Schedule, 12-09, Allowance, Returns [Member] SEC Schedule, 12-09, Allowance, Returns Award Type [Axis] Award Type [Axis] Common stock, $0.01 par value per share; 125,000,000 shares authorized; 56,081,993 shares and 51,617,639 shares issued and outstanding as of June 30, 2020 and December 31, 2019, respectively Common Stock, Value, Issued Maturities of marketable securities Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-sale Research and development Research and Development Expense Schedule of Marketable Securities Marketable Securities [Table Text Block] Interest and other income, net Other Nonoperating Income (Expense) Accrued Expenses And Other Current Liabilities Accrued Expenses And Other Current Liabilities [Member] Accrued Expenses And Other Current Liabilities Subsequent Events [Abstract] Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax Inventory Increase (Decrease) in Inventories Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Geographical [Axis] Geographical [Axis] Unaudited Interim Financial Information Unaudited Interim Financial Information [Policy Text Block] Unaudited Interim Financial Information Policies Accumulated Deficit Retained Earnings [Member] Milestone Two [Axis] Milestone Two [Axis] Subsequent Event [Line Items] Subsequent Event [Line Items] Operating lease assets Operating Lease, Right-of-Use Asset Revenue from External Customer [Line Items] Revenue from External Customer [Line Items] Long-term marketable securities Marketable Securities, Noncurrent Property and equipment purchases included in accounts payable and accrued expenses and other current liabilities Capital Expenditures Incurred but Not yet Paid Equity Components [Axis] Equity Components [Axis] Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Domain] Document Period End Date Document Period End Date Percentage of accounts receivable Product Sale Receivables From Major Customers, Percentage Receivables From Major Customers Associated with Product Sales as a Percentage of Total Receivables From Product Sales Statement [Table] Statement [Table] Entity Registrant Name Entity Registrant Name Total stockholders' equity Beginning balance Ending balance Stockholders' Equity Attributable to Parent Concentration Risk Type [Domain] Concentration Risk Type [Domain] Other long-term liabilities Increase (Decrease) in Other Operating Liabilities Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] Cash flows from investing activities: Net Cash Provided by (Used in) Investing Activities [Abstract] Net accretion of discounts on marketable securities Accretion (Amortization) of Discounts and Premiums, Investments Maximum Maximum [Member] Government rebates and other incentives SEC Schedule, 12-09, Allowance, Government Rebates And Other Incentives [Member] SEC Schedule, 12-09, Allowance, Government Rebates And Other Incentives Estimated Fair Value Total Marketable securities Debt Securities, Available-for-sale Depreciation expense Depreciation, Depletion and Amortization Chargebacks and administrative fees SEC Schedule, 12-09, Allowance, Chargebacks And Administrative Fees [Member] SEC Schedule, 12-09, Allowance, Chargebacks And Administrative Fees Additional offering price of common stock (in dollars per share) Shares Issued, Price Per Share Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Cash paid for interest Interest Paid, Excluding Capitalized Interest, Operating Activities Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Accumulated deficit Retained Earnings (Accumulated Deficit) Preferred stock, $0.01 par value per share; 5,000,000 shares authorized; no shares issued or outstanding Preferred Stock, Value, Issued Supplemental disclosure of cash flow information: Other Noncash Investing and Financing Items [Abstract] Massachusetts MASSACHUSETTS Total Cash equivalents Cash and Cash Equivalents, Fair Value Disclosure Security Exchange Name Security Exchange Name Entity Tax Identification Number Entity Tax Identification Number Potential dilutive securities excluded from computation of diluted net loss per common share (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Unrealized gains (losses) on marketable securities Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, after Tax SEC Schedule, 12-09, Valuation and Qualifying Accounts Disclosure [Line Items] Schedule of Accrued Expenses and Other Current Liabilities SEC Schedule, 12-09, Valuation and Qualifying Accounts Disclosure [Line Items] Additional paid-in capital Additional Paid in Capital, Common Stock Employee Stock Purchase Plan (ESPP) Employee Stock Purchase Plan Espp [Member] Employee Stock Purchase Plan Espp [Member] Net cash flows used in operating activities Net Cash Provided by (Used in) Operating Activities Equity Component [Domain] Equity Component [Domain] Milestone [Domain] Milestone [Domain] Trading Symbol Trading Symbol Customer One [Member] Customer One [Member] Customer One Document Transition Report Document Transition Report Options to purchase common stock Share-based Payment Arrangement, Option [Member] Supply commitment amount Supply Commitment, Remaining Minimum Amount Committed Accounts Receivable Accounts Receivable [Policy Text Block] Commercial Milestone Commercial Milestone [Member] Increase in restricted investments Increase (Decrease) of Restricted Investments Raw materials Inventory, Raw Materials, Net of Reserves Trade discounts and allowances SEC Schedule, 12-09, Allowance, Trade Discounts And Allowances [Member] SEC Schedule, 12-09, Allowance, Trade Discounts And Allowances Balance Sheet Location [Domain] Balance Sheet Location [Domain] Range [Domain] Statistical Measurement [Domain] Adjustments to reconcile net loss to net cash flows used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Marketable Securities and Fair Value Measurements Financial Instruments Disclosure [Text Block] Unvested employee stock purchase plan shares Employee stock purchase plan Employee Stock [Member] Net cash flows provided by financing activities Net Cash Provided by (Used in) Financing Activities Income Statement [Abstract] Income Statement [Abstract] Stock-Based Awards Share-based Payment Arrangement [Text Block] Professional fees Accrued Professional Fees, Current Balance Sheet Location [Axis] Balance Sheet Location [Axis] Beginning balance Ending balance Revenue-related reserves SEC Schedule, 12-09, Valuation Allowances and Reserves, Amount