X0306 4 2021-12-15 0 0001654151 Deciphera Pharmaceuticals, Inc. DCPH 0001325710 Sherman Matthew L C/O DECIPHERA PHARMACEUTICALS, INC. 200 SMITH STREET WALTHAM MA 02451 0 1 0 0 EVP & Chief Medical Officer Common Stock 2021-12-15 4 A 0 11100 0.00 A 57274 D Stock Option (Right to Buy) 9.23 2021-12-15 4 A 0 82265 0.00 A 2031-12-14 Common Stock 82265 82265 D The reporting person was awarded 11,100 Restricted Stock Units ("RSUs") under the Issuer's 2017 Stock Option and Incentive Plan (the "2017 Plan"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs shall vest in two equal installments on June 15, 2022 and June 15, 2023, subject to continuous service with the Issuer or a Subsidiary (as defined in the 2017 Plan) through such dates. The RSUs may be settled only by delivering shares of the Issuer's Common Stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance. Includes 145 shares acquired under the Issuer's 2017 Employee Stock Purchase Plan on November 12, 2021. This stock option was issued pursuant to the 2017 Plan. The option shall vest in two equal installments on June 15, 2022 and June 15, 2023, subject to continuous service with the Issuer or a Subsidiary (as defined in the 2017 Plan) through each vesting date. /s/ Jeffrey Held, Attorney-in-Fact 2021-12-17