X0306 4 2019-03-07 0 0001720893 BioXcel Therapeutics, Inc. BTAI 0001653967 Votruba Michal C/O BIOXCEL THERAPEUTICS, INC. 555 LONG WARF DRIVE NEW HAVEN CT 06511 1 0 0 0 Stock Options (Right to Buy) 7.91 2019-03-07 4 D 0 10000 7.91 D 2029-03-07 Common Stock 10000 0 D The shares underlying this stock option vest as follows: one-third on each of 3/7/2020, 3/7/2021 and 3/7/2022, subject to the Reporting Person's continuous service to the Issuer through such dates. The Reporting Person immediately and automatically assigned these stock options to RSJ Investments SICAV a.s. ("RSJ") pursuant to the policies of RSJ regarding stock ownership by its employees, as documented by an Agreement between the Reporting Person and RSJ. The Reporting Person is serving on the Board of the Issuer with the permission of RSJ. The Reporting Person does not beneficially own any non-derivative securities. /s/ Michal Votruba 2019-03-18