<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144/A</submissionType>
    <previousAccessionNumber>0001628280-25-046836</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001653881</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001724521</issuerCik>
      <issuerName>Arcus Biosciences, Inc.</issuerName>
      <secFileNumber>001-38419</secFileNumber>
      <issuerAddress>
        <com:street1>3928 POINT EDEN WAY</com:street1>
        <com:city>Hayward</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94545</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>510-694-6200</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Robert C. Goeltz II</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>555 California St</com:street1>
          <com:street2>Ste 1800</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94104</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>5000</noOfUnitsSold>
      <aggregateMarketValue>100000</aggregateMarketValue>
      <noOfUnitsOutstanding>106430976</noOfUnitsOutstanding>
      <approxSaleDate>10/28/2025</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/15/2023</acquiredDate>
      <natureOfAcquisitionTransaction>10/28/2025</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcus Biosciences</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
      <paymentDate>12/15/2023</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Form 144 being modified to add in the 10b5-1 plan adoption date. 10b5-1 plan modified on 2/23/2024.</remarks>
    <noticeSignature>
      <noticeDate>10/28/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>03/07/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>Robert Goeltz</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
