X0306 5 2018-12-31 0 1 0001653821 CEN BIOTECH INC CENBF 0001736911 Byrne Joseph A. 300-3295 QUALITY WAY WINDSOR, ONTARIO, CANADA A6 N8T 3R9 ONTARIO, CANADA 1 1 Chief Executive Officer* Common Stock 2018-01-14 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-02-14 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-03-15 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-04-17 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-05-14 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-06-15 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-07-16 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-08-16 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-09-16 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-10-17 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-11-20 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-12-14 4 J 0 L 2000 0 A 1425265 D Common Stock 2018-01-14 4 J 0 L 4000 0 A 1425265 I By Spouse Common Stock 2018-02-14 4 J 0 L 4000 0 A 1425265 I By Spouse Common Stock 2018-03-15 4 J 0 L 4000 0 A 1425265 I By Spouse Common Stock 2018-04-17 4 J 0 L 4000 0 A 1425265 I By Spouse Common Stock 2018-05-14 4 J 0 L 4000 0 A 1425265 I By Spouse Common Stock 2018-06-15 4 J 0 L 4000 0 A 1425265 I By Spouse Common Stock 2018-07-16 4 J 0 L 4000 0 A 1425265 I By Spouse Common Stock 2018-08-16 4 J 0 L 4000 0 A 1425265 I By Spouse Common Stock 2018-09-16 4 J 0 L 4000 0 A 1425265 I By Spouse Common Stock 2018-10-17 4 J 0 L 4000 0 A 1425265 I By Spouse Common Stock 2018-11-20 4 J 0 L 4000 0 A 1425265 I By Spouse Common Stock 2018-12-14 4 J 0 L 4000 0 A 1425265 I By Spouse 24,000 shares of the issuer held by the reporting person were issued as consideration for extending the maturity date of a promissory note dated January 24, 2018 and were acquired in increments of 2,000 shares on the following dates: 12/14/18; 11/20/18; 10/17/18; 9/16/18; 8/16/18; 7/16/18; 6/15/18; 5/14/18; 4/17/18; 1/24/18; 2/14/18; and 3/15/18. 48,000 shares of common stock of the issuer were issued to the Reporting Person's spouse as consideration for extending the maturity date of a promissory note dated January 14, 2018 and were acquired in increments of 4,000 on the following dates: 1/14/18; 2/14/18; 3/15/18; 4/17/18; 5/14/18; 6/15/18; 7/16/18; 8/16/18; 9/16/18; 10/17/18; 11/20/18; and 12/14/18. 1,377,265 shares were beneficially owned by the Reporting Person of which 76,123 shares were issuable upon conversion of a convertible note held by the Reporting Person and 48,000 shares were held by the Reporting Person's spouse at 12/31/2018. *The reporting person served as the Chief Executive Officer and member of the Board of the Issuer from July 2017 until November 13, 2019, when the reporting person resigned from all positions with the Issuer. The reporting person was appointed as President and a member of the Board of the Issuer effective April 19, 2021. /s/ Joseph Byrne 2021-04-27