Note 18 - Restatement - Effect on Previously Issued Consolidated Financial Statements (Details) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017	Dec. 31, 2017	Dec. 31, 2016
Deferred lease expense	$ 176,482	$ 230,786	$ 176,482	$ 230,786	$ 217,210
Intangible assets, net	5,911,974	6,336,787	5,911,974	6,336,787	6,230,583
Patent acquisition liability	620,000	5,000,000	620,000	5,000,000	5,000,000
Common stock
Additional paid-in capital	14,169,809	82	14,169,809	82	9,110,041
Accumulated deficit	(32,493,786)	(17,521,440)	(32,493,786)	(17,521,440)	$ (28,124,692)
Consulting fees	82,200	154,625	142,685	352,225
Consulting fees and payroll – related parties	35,014	39,017	112,053	122,744
General and administrative	355,441	357,053	1,491,875	1,145,944
Interest expense	620,855	521,518	1,824,028	1,516,305
Interest expense – related parties	$ 106,708	83,323	$ 316,286	246,747
Previously Reported [Member]
Deferred lease expense
Intangible assets, net		2,209,152		2,209,152
Patent acquisition liability
Common stock		85		85
Additional paid-in capital		10,000		10,000
Accumulated deficit		(16,889,864)		(16,889,864)
Consulting fees		195,381		498,158
Consulting fees and payroll – related parties
General and administrative		272,438		1,145,632
Interest expense		518,894		1,552,275
Interest expense – related parties		85,947		210,777
Restatement Adjustment [Member]
Deferred lease expense		230,786		230,786
Intangible assets, net		4,127,635		4,127,635
Patent acquisition liability		5,000,000		5,000,000
Common stock		(85)		(85)
Additional paid-in capital		(9,918)		(9,918)
Accumulated deficit		(631,576)		(631,576)		$ (654,453)
Consulting fees		(40,756)		(145,933)
Consulting fees and payroll – related parties		39,017		122,744
General and administrative		84,615		312
Interest expense		2,624		(35,970)
Interest expense – related parties		$ (2,624)		$ 35,970