Note 18 - Restatement - Effect on Previously Issued Consolidated Financial Statements (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Dec. 31, 2017	Dec. 31, 2016
Deferred lease expense	$ 190,058	$ 244,362	$ 190,058	$ 244,362	$ 217,210
Intangible assets, net	6,018,177	6,442,990	6,018,177	6,442,990	6,230,583
Patent acquisition liability	620,000	5,000,000	620,000	5,000,000	5,000,000
Accrued expenses	339,977	287,649	339,977	287,649	295,874
Common stock
Additional paid-in capital	13,974,509	82	13,974,509	82	9,110,041
Accumulated deficit	(31,105,003)	(16,316,810)	(31,105,003)	(16,316,810)	$ (28,124,692)
Consulting fees	48,500	107,600	60,485	197,600
Consulting fees and payroll – related parties	45,839	83,727	77,039	83,727
General and administrative	694,595	414,160	1,136,434	788,891
Interest expense	608,670	504,570	1,203,173	994,787
Interest expense – related parties	$ 105,292	83,285	$ 209,578	163,424
Previously Reported [Member]
Deferred lease expense
Intangible assets, net		2,246,052		2,246,052
Patent acquisition liability
Accrued expenses		287,650		287,650
Common stock		85		85
Additional paid-in capital		10,000		10,000
Accumulated deficit		(15,758,015)		(15,758,015)
Consulting fees		212,326		302,327
Consulting fees and payroll – related parties
General and administrative		310,283		873,645
Interest expense		62,825		1,033,381
Interest expense – related parties		525,030		124,830
Restatement Adjustment [Member]
Deferred lease expense		244,362		244,362
Intangible assets, net		4,196,938		4,196,938
Patent acquisition liability		5,000,000		5,000,000
Accrued expenses		(3)		(3)
Common stock		(85)		(85)
Additional paid-in capital		(9,918)		(9,918)
Accumulated deficit		(548,700)		(548,700)		$ (654,453)
Consulting fees		(104,726)		(104,727)
Consulting fees and payroll – related parties		83,727		83,727
General and administrative		103,877		(84,754)
Interest expense		441,745		(38,594)
Interest expense – related parties		$ (441,745)		$ 38,594