Note 18 - Restatement - Effect on Previously Issued Consolidated Financial Statements (Details) - USD ($)	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017	Dec. 31, 2016
Deferred lease expense		$ 257,937
Intangible assets, net		6,549,193
Patent acquisition liability		5,000,000
Accrued expenses		287,655
Common stock
Additional paid-in capital		82
Accumulated deficit	$ (29,445,462)	(15,092,515)
Consulting fees	11,985	90,000
General and administrative	$ 441,839	374,731
Previously Reported [Member]
Deferred lease expense
Intangible assets, net		2,282,952
Patent acquisition liability
Accrued expenses		297,650
Common stock		85
Additional paid-in capital		10,000
Accumulated deficit		(14,636,693)
Consulting fees		100,000
General and administrative		563,362
Restatement Adjustment [Member]
Deferred lease expense		257,937
Intangible assets, net		4,266,241
Patent acquisition liability		5,000,000
Accrued expenses		(9,995)
Common stock		(85)
Additional paid-in capital		(9,918)
Accumulated deficit		(455,822)	$ (654,453)
Consulting fees		(10,000)
General and administrative		$ (188,631)