Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2019		69,052,873
Beginning Balance at Dec. 31, 2019	$ 194,743	$ 7	$ 414,414	$ 142	$ (219,820)
Issuance of common stock upon follow-on public offering, net of issuance costs of $1,148 (in shares)		9,602,500
Issuance of common stock upon follow-on public offering, net of issuance costs	224,511	$ 1	224,510
Exercise of stock options (in shares)		655,772
Exercise of stock options	6,331		6,331
Purchase of common stock under employee stock purchase plan (in shares)		86,870
Purchase of common stock under employee stock purchase plan	1,179		1,179
Forfeiture of restricted common stock		(81,754)
Stock-based compensation	30,522		30,522
Unrealized gain (loss) on marketable securities	472			472
Net loss	(190,228)				(190,228)
Ending balance (in shares) at Dec. 31, 2020		79,316,261
Ending Balance at Dec. 31, 2020	267,530	$ 8	676,956	614	(410,048)
Exercise of stock options (in shares)		2,395,223
Exercise of stock options	28,530		28,530
Vesting of restricted stock units		156,420
Purchase of common stock under employee stock purchase plan (in shares)		136,331
Purchase of common stock under employee stock purchase plan	1,765		1,765
Forfeiture of restricted common stock		(18,043)
Stock-based compensation	40,785		40,785
Unrealized gain (loss) on marketable securities	(1,557)			(1,557)
Net loss	$ (36,329)				(36,329)
Ending balance (in shares) at Dec. 31, 2021	81,986,192	81,986,192
Ending Balance at Dec. 31, 2021	$ 300,724	$ 8	748,036	(943)	(446,377)
Exercise of stock options (in shares)		298,238
Exercise of stock options	3,059		3,059
Vesting of restricted stock units		414,578
Purchase of common stock under employee stock purchase plan (in shares)		196,710
Purchase of common stock under employee stock purchase plan	1,455		1,455
Stock-based compensation	46,146		46,146
Unrealized gain (loss) on marketable securities	(3,632)			(3,632)
Net loss	$ (133,310)				(133,310)
Ending balance (in shares) at Dec. 31, 2022	81,986,192	82,895,718
Ending Balance at Dec. 31, 2022	$ 214,442	$ 8	$ 798,696	$ (4,575)	$ (579,687)