Leases - Additional Information (Detail) $ in Thousands		1 Months Ended				12 Months Ended
	Jun. 30, 2018 ft²	Nov. 30, 2021 ft²	Dec. 31, 2020 USD ($) ft²	Oct. 31, 2020 USD ($) ft²	May 31, 2019 ft²	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	May 31, 2022 ft²
Lessee Lease Description [Line Items]
Tenant improvement allowance | $						$ 15,700
Amount form letter of credit | $			$ 1,472			$ 1,472	$ 1,472	$ 1,472
Lease expiration year						2029
Operating lease, renewal period						10 years
Operating lease term						The lease expires in 2029 with an option to renew for a period of ten years.
Weighted average remaining lease term for operating leases						6 years 2 months 12 days
Weighted average discount rate for operating leases						8.50%
Cash paid for amounts included In measurement of lease liabilities | $						$ 8,200	$ 7,900	$ 6,900
Offices and Laboratory Facilities | South San Francisco
Lessee Lease Description [Line Items]
Area under lease | ft²	105,000		23,600
Area under sublease | ft²		7,132			25,000
Sublease expiration month and year						2022-12	2021-11
Additional area sublease expiration month and year						2023-11
Operating sublease, existence of option to extend						true
Additional area of property in lease | ft²									13,150
Offices and Laboratory Facilities | South San Francisco
Lessee Lease Description [Line Items]
Tenant improvement allowance | $				$ 400
Area of property | ft²				18,700
Lease, description						In October 2020, the Company signed a lease agreement to lease approximately 18,700 square feet of office and laboratory space in Newark, California. The lease term ends on February 6, 2028 with an option to extend for an additional five years. The landlord is obligated to pay for up to $0.4 million of tenant improvements.
Lease expiration date				Feb. 06, 2028
Extend for an additional lease term				5 years