Collaboration Agreements - Additional Information (Details) $ in Thousands			1 Months Ended			12 Months Ended
	Aug. 17, 2021 USD ($)	Jul. 01, 2021 USD ($)	Jan. 31, 2022 USD ($)	Jan. 31, 2018 USD ($)	Oct. 31, 2017 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Feb. 28, 2023 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Deferred revenue						$ 444,900	$ 307,900
Research and development expense						210,418	189,407	$ 156,869
GlaxoSmithKline plc
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Effective date of agreement	Aug. 17, 2021
Upfront payments		$ 700,000				$ 700,000
Upfront payment received	$ 500,000		$ 200,000
Percentage Of Development Cost						0.60
Collaboration revenue						$ 62,900	192,100
Research and development expense						14,700	8,800
GlaxoSmithKline plc | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Additional milestone payments per program related to initiation of certain clinical studies and regulatory approval						$ 1,500,000
Alector
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage Of Development Cost						0.40
AbbVie Biotechnology Limited
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront payments					$ 205,000	$ 205,000
Upfront payment received				$ 200,000	5,000
Collaboration revenue						70,700	14,900	$ 21,100
Deferred revenue						46,700	$ 117,400
Exclusive option rights exercised for each program					250,000
AbbVie Biotechnology Limited | Subsequent Event
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments									$ 17,800
AbbVie Biotechnology Limited | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Additional milestone payments per program related to initiation of certain clinical studies and regulatory approval					$ 225,000
Innovent
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration revenue						0
Development milestone						11,500
Sales milestone						$ 112,500