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Collaboration and License Agreements - Asklepios Biopharmaceutical, Inc. License 10-K (Details) - USD ($)
$ in Thousands
12 Months Ended
May 29, 2015
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Collaboration and License Agreements        
Research and Development Expense   $ 150,391 $ 58,892 $ 27,493
License Agreement | Asklepios Biopharmaceutical, Inc.        
Collaboration and License Agreements        
Up-front payment made $ 1,000      
Potential milestone payments to be paid $ 9,600      
Research and Development Expense       $ 1,000
Period of prior written notice to terminate agreement 6 months      
Up-front Payment Arrangement [Member] | License Agreement | Asklepios Biopharmaceutical, Inc.        
Collaboration and License Agreements        
Up-front payment made $ 1,000