Quarterly Financial Information (Unaudited) (Tables)

12 Months Ended

Dec. 31, 2017

Quarterly Financial Information (Unaudited)

Summary of quarterly financial information

	Quarter Ended
	December 31,		September 30,		June 30,		March 31,
	2017		2017		2017		2017
Revenue	$	—	$	—	$	—	$	—
Loss from operations	$	(82,523)	$	(49,520)	$	(58,360)	$	(29,964)
Interest income	$	858	$	881	$	331	$	246
Net loss and comprehensive loss	$	(81,665)	$	(48,639)	$	(58,029)	$	(29,718)
Basic and diluted net loss per common share (1)	$	(2.55)	$	(1.52)	$	(2.07)	$	(1.07)
Weighted-average basic and diluted common shares outstanding		32,030		31,941		27,972		27,734

	Quarter Ended
	December 31,		September 30,		June 30,		March 31,
	2016		2016		2016		2016
Revenue	$	—	$	—	$	—	$	—
Loss from operations	$	(25,547)	$	(21,180)	$	(15,798)	$	(20,889)
Interest income	$	172	$	99	$	79	$	53
Net loss and comprehensive loss	$	(25,375)	$	(21,082)	$	(15,719)	$	(20,836)
Basic and diluted net loss per common share (1)	$	(0.92)	$	(0.87)	$	(0.68)	$	(1.24)
Weighted-average basic and diluted common shares outstanding		27,678		24,166		23,014		16,775

(1)The sum of the four quarters of net loss per share for 2017 and 2016 may not add to the full year net loss per share amount due to rounding and/or the use of quarter-to-date weighted average shares to calculate the net loss per share amount in each respective quarter.