X0306 4 2021-06-23 0 0001659323 Iterum Therapeutics plc ITRM 0001652410 Hecht Beth C/O ITERUM THERAPEUTICS PLC, BLK 3 FL. 3, HARCOURT CENTRE, HARCOURT ST. DUBLIN L2 2 IRELAND 1 0 0 0 Restricted Stock Units 2021-06-23 4 A 0 36798 0.00 A Ordinary Shares 36798 36798 D Each restricted share unit ("RSU") represents the contingent right to receive one ordinary share upon vesting of the RSU. Subject to the reporting person providing continuous service to the Issuer and the other terms and conditions of the Issuer's 2018 Amended and Restated Equity Incentive Plan, as amended, the RSUs shall vest in full on June 23, 2022. /s/ Beth P. Hecht 2021-06-25