X0306 4 2017-03-01 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001652208 Gulino Richard L. 2200 PENNSYLVANIA AVENUE SUITE 300E WASHINGTON DC 20037 0 1 0 0 SVP, General Counsel & Sec. Restricted Stock Unit 2017-03-01 4 A 0 30000 A 39100 D Employee Stock Option (Right to Buy) 14.50 2017-03-01 4 A 0 70000 0.00 A 2027-02-28 Common Stock 70000 70000 D The Restricted Stock Units ("RSU") shall vest in four (4) equal annual installments beginning March 1, 2018, provided Reporting Person remains continuously employed by the Issuer through each annual vesting date. Vested shares will be delivered on the First Permissable Trading Day (as defined in the RSU Agreement) that occurs on or after the day when the RSUs vest. Each RSU represents a contingent right to receive a share of the Issuer's common stock. The shares subject to this option shall vest in forty-eight (48) equal monthly installments beginning March 1, 2017, provided Reporting Person remains continuously employed by the Issuer through each monthly vesting date. /s/ Richard L. Gulino 2017-03-03