X0206 3 2022-02-23 0 0001652130 Intellia Therapeutics, Inc. NTLA 0001914448 Clark Eliana C/O INTELLIA THERAPEUTICS, INC. 40 ERIE STREET CAMBRIDGE MA 02139 0 1 0 0 EVP, Chief Technical Officer Common Stock 5638 D Stock Option (right to buy) 12.27 2030-02-02 Common Stock 62750 D Stock Option (right to buy) 57.71 2031-03-02 Common Stock 31500 D Includes a grant of 5,250 restricted stock units representing a contingent right to receive one share of Intellia common stock for each restricted stock unit. This option was granted on February 3, 2020 with respect to 75,000 shares of Common Stock, with 25% vesting on January 6, 2021 and the remaining 75% vesting in 36 substantially equal monthly installments thereafter. This option was granted on March 3, 2021 with respect to 31,500 shares of Common Stock, with 25% vesting on January 1, 2022 and the remaining 75% vesting in thirty-six (36) substantially equal monthly installments thereafter. /s/ James Basta, attorney-in-fact 2022-03-07