Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Income Tax Benefit [Line Items]
Net operating loss carryforwards, federal	$ 954,000	$ 852,100
Capitalized research and development costs	$ 365,800	322,600
Amortization of costs for tax purpose description	The Company will amortize these costs for tax purposes over 5 years if the research and development was performed in the U.S. and over 15 years if the research and development was performed outside the U.S.
Taxable Income available for the period the loss was generated	20 years
Increase in valuation allowance	$ 161,300	150,000	$ 163,900
Research and development and other credit	151,333	101,326
Unrecognized tax benefits	$ 0
Operating Loss Carryforward Indefinitely Begins to Expire in 2034 [Member]
Income Tax Benefit [Line Items]
Net operating loss carryover, percentage of taxable income	100.00%
Operating Loss Carryforward Indefinitely [Member]
Income Tax Benefit [Line Items]
Net operating loss carryover, percentage of taxable income	80.00%
Federal [Member]
Income Tax Benefit [Line Items]
Net operating loss carryforwards, expiration date description	begin to expire in 2034
Net operating loss carryforwards, begins to expiring year	2034
Tax credit carryforwards, expiration date description	begin to expire in 2034
Tax credit carryforwards, begins to expiring year	2034
Federal [Member] | Operating Loss Carryforward Indefinitely Begins to Expire in 2034 [Member]
Income Tax Benefit [Line Items]
Net operating loss carryforwards, with expiration date	$ 36,900
Federal [Member] | Operating Loss Carryforward Indefinitely [Member]
Income Tax Benefit [Line Items]
Net operating loss carryforwards with no expiration date	917,100
Federal [Member] | Tax Carryforwards Begin to Expire in 2034 [Member]
Income Tax Benefit [Line Items]
Tax credit carryforwards, with expiration date	$ 100,700	63,400
State [Member]
Income Tax Benefit [Line Items]
Net operating loss carryforwards, expiration date description	begin to expire in 2034.
Net operating loss carryforwards, begins to expiring year	2034
Research and development and other credit	$ 64,100	48,000
Research and development tax credits, expiration year	2029
Research and development tax credits, expiration date description	begin to expire in 2029
State [Member] | Operating Loss Carryforward Begin to Expire In 2034 [Member]
Income Tax Benefit [Line Items]
Net operating loss carryforwards, with expiration date	$ 922,800	$ 797,800