Leases - Additional Information (Detail) $ in Thousands		1 Months Ended	3 Months Ended
	Feb. 28, 2022 ft²	Feb. 28, 2022 ft²	Mar. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)
Lessee Lease Description [Line Items]
Operating lease right-of-use assets | $			$ 128,265	$ 133,076
Albany Lease [Member]
Lessee Lease Description [Line Items]
Operating lease, existence of option to extend			true
840 Winter Street Lease [Member]
Lessee Lease Description [Line Items]
Area of space leased | ft²	140,000
Operating lease, description			In February 2022, the Company entered into an agreement to lease approximately 140,000 square feet of manufacturing space located at 840 Winter Street, Waltham, Massachusetts (the “840 Winter Lease”), which will provide the Company with the ability to manufacture its own products in a good manufacturing practice (“GMP”) compliant facility as well as to supplement the Company’s current leased premises in Cambridge, Massachusetts. The 840 Winter Lease, including the obligation to pay rent, is expected to commence in 2024 for an
Term of lease	12 years	12 years
Base rent per square foot for first year | ft²		73.50
Operating lease, options to extend			The Company has the option to extend the 840 Winter Lease for two five-year terms.
Percentage of Annual Increase			3.00%
MemorialDrive640Member
Lessee Lease Description [Line Items]
Operating lease, description			n January 2023, the Company performed a remeasurement of their lease for office and laboratory space located at 640 Memorial Drive, Cambridge, Massachusetts, as the Company’s rentable square footage had been modified. This remeasurement included an update to the incremental borrowing rate from 7.99% to 8.4%, and resulted in a decrease in the right of use asset and lease liability of $0.2 million.
Operating lease right-of-use assets | $			$ 200
Maximum
Lessee Lease Description [Line Items]
Incremental borrowing rate			8.40%
Minimum
Lessee Lease Description [Line Items]
Incremental borrowing rate			7.99%